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  Feb 24, 2012                  

me+ME: A good report on XMRV

There is - what seems to me - a good report on XMRV by Harriet Groom and Kate Bishop, of the "Division of Virology, MRC National Institute for Medical Research (..) UK".  This is the abstract, with a link to a download page of the full pdf (352 Kb) in the title:

The tale of xenotropic murine leukemia virus-related virus
Harriet C.T. Groom and Kate N. Bishop

In 2006, a new retrovirus was isolated from prostate cancer patient tissue. Named xenotropic murine leukemia virus-related virus (XMRV), this was potentially the third class of retrovirus to be pathogenic in humans. XMRV made a more dramatic impact on the wider scientific community, and indeed the media, in 2009 when it was reported to be present in a remarkably high proportion of patients with chronic fatigue syndrome as well as a significant, albeit smaller, proportion of healthy controls. The apparent strong link to disease and the fear of a previously unknown retrovirus circulating in the general population lead to a surge in XMRV research. Subsequent studies failed to find an association of XMRV with disease and, in most cases, failed to find the virus in human samples. In 2011, the case against XMRV and human disease strengthened, ending with several decisive publications revealing the origin of the virus and demonstrating contamination of samples. In this review, we outline the passage of research on XMRV and its potential association with disease from its isolation to the present day, where we find ourselves at the end of a turbulent story.

It seems a good report and survey, and it also is a considerable relief to read compared with the APA-prose that I have been writing about lately: At least they use quantifiers, logic and know some probability theory. And apart from XMRV-technicalities I never read up on, which I can't follow, the arguments make logical sense.

The summary is as in ERVs: It still dead, though ERV wasn't mentioned. It also doesn't mention psychiatry or psychiatrists, and seems fair about patients, indeed correctly using "some".

It is ten pages of text in the pdf, with 8 pages of references and at the end a table of XMRV-related research in other diseases than ME/CFS and a figure that is said to be a "Simplified schematic of the life cycle of a simple exogenous retrovirus", that qua abstract art looks a lot better than I was exposed to under that label in Dutch museums (*), and even represents something.

(*) "Abstract Art: A product of the untalented, sold by the unprincipled to the utterly bewildered." (All Capp)

Corrections, if any are necessary, have to be made later.


As to ME/CFS (that I prefer to call ME):
1.  Anthony Komaroff Ten discoveries about the biology of CFS (pdf)
3.  Hillary Johnson The Why
4.  Consensus of M.D.s Canadian Consensus Government Report on ME (pdf)
5.  Eleanor Stein Clinical Guidelines for Psychiatrists (pdf)
6.  William Clifford The Ethics of Belief
7.  Paul Lutus

Is Psychology a Science?

8.  Malcolm Hooper Magical Medicine (pdf)
 Maarten Maartensz
ME in Amsterdam - surviving in Amsterdam with ME (Dutch)
 Maarten Maartensz Myalgic Encephalomyelitis

Short descriptions of the above:                

1. Ten reasons why ME/CFS is a real disease by a professor of medicine of Harvard.
2. Long essay by a professor emeritus of medical chemistry about maltreatment of ME.
3. Explanation of what's happening around ME by an investigative journalist.
4. Report to Canadian Government on ME, by many medical experts.
5. Advice to psychiatrist by a psychiatrist who understa, but nds ME is an organic disease
6. English mathematical genius on one's responsibilities in the matter of one's beliefs:

7. A space- and computer-scientist takes a look at psychology.
8. Malcolm Hooper puts things together status 2010.
9. I tell my story of surviving (so far) in Amsterdam/ with ME.
10. The directory on my site about ME.

See also: ME -Documentation and ME - Resources
The last has many files, all on my site to keep them accessible.

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